Table 1.
Studies of Ih and HCN channels in thalamocortical relay neurons of rat (WAG/Rij; GAERS) and mouse (HCN2-/- knock-out) models of Absence epilepsy.
| Reference | Animal | Tissue | Expression |
Ih |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HCN1 | HCN2 | HCN3 | HCN4 | V1/2 | Amplitude | cAMP sensitivity | τ act | |||
| Kanyshkova et al., 2012 | WAG/Rij versus ACI | TC relay neurons (dLGN, P90; VB, P30) | ↑ Prot. (dLGN) / = Prot. (VB) | const. | (↑) Prot. on P7 | const. | -7.9 mV (dLGN) -3 mV (VB) | ↑ ~1.5-fold (dLGN) | Reduced | Faster |
| Budde et al., 2005 | WAG/Rij versus ACI | TC relay (dLGN, P16–29) | ↑ mRNA and Prot. (dLGN) | const. | const. | const. | -5.2 mV (dLGN) -2.8 mV (VB) | Not analyzed systematically | Reduced | Faster |
| Strauss et al., 2004 | WAG/Rij versus ACI and Wistar | Pyramidal (layers 2–3) somatosensory cortex | ccc Prot.∗ / = mRNA | const. | const. | const. | +9 mV (somatic) | ↓ ~0.5-fold (somatic) | n.t. | Slower |
| Kole et al., 2007 | WAG/Rij versus Wistar | Pyramidal (layer 5) somatosensory cortex | ↓ Prot. (68%) | const. | n.t. | n.t. | const. (dendritic) | ↓ ~0.5-fold (dendritic) | n.t. | n.t. |
| Ludwig et al., 2003 | HCN2-/- mouse | TC relay neurons and hippocampus | const. | -/- | const. | const. | -27 mV (TC) -2 mV (CA) |
↓ 80% (TC) ↓ 39% (CA) |
Reduced | n.t. |
| Cain et al., 2014 | GAERS versus NEC | TC relay neurons (VB, P7–P150) | ↑ Prot. (VB) | const. | ↑ Prot. (VB) | const. | const. | ↑ ~2-fold | n.t. | n.t. |
| Kuisle et al., 2006 | GAERS versus NEC | TC relay neurons (VB, 19–24 days, 3–8 months) | ↑ mRNA (VB, NRT) | const. | n.t. | const. | const. | const. | Reduced | n.t. |
CA pyramidal neurons of the hippocampus; const. = constant; dLGN = dorsal lateral geniculate nucleus; GAERS = Genetic Absence Epilepsy in Rats from Strasbourg; NEC = non-epileptic controls; NRT = Nucleus reticularis thalami; n.t. = not tested; Prot. = Protein; TC = thalamocortical; VB = ventrobasal thalamic complex; ‘↑’ = up-regulated; ‘↓’ = down-regulation; ‘ = ’ = not regulated. ∗hippocampus ↓46%, neocortex ↓21%, cerebellum ↓57%.