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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Osteoarthritis Cartilage. 2015 Nov;23(11):1999–2008. doi: 10.1016/j.joca.2015.06.012

Figure 3.

Figure 3

Inhibiting intra-articular NGF signaling at day 1 after FJD did not alter pain or spinal neuronal hyperexcitability. (A) The forepaw withdrawal threshold decreased at all days after FJD+veh compared to FJD+anti-NGF (*p<0.041). FJD+anti-NGFD1 also exhibited decreased thresholds at all days compared to FJD+anti-NGF (#p<0.043). (B) At day 7, there were fewer spikes evoked by noxious von Frey stimulation (26g) for FJD+anti-NGF relative to FJD+veh (*p<0.002) and FJD+anti-NGFD1 (#p<0.022), but both FJD+anti-NGF (*p<0.001) and FJD+anti-NGFD1 (+p<0.001) exhibited fewer evoked spikes than FJD+veh for a noxious pinch. (C–E) Representative spikes are shown for the 26g and pinch stimuli for each group. Datasets for the FJD+veh and FJD+anti-NGF groups are reproduced from Figure 2. FJD: facet joint distraction; NGF: nerve growth factor; d: day.