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. 2015 Nov 3;5:16109. doi: 10.1038/srep16109

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(A) Neonatal colonic inflammation (NCI) significantly increased the visceromoter response to colorectal distention (CRD) 6 weeks after neonatal colonic infusion of acetic acid (AA). *p < 0.05, compared with control (CON). (B) Systemic administration of nonselective βAR antagonist propranolol (Prop) attenuated NCI-induced visceral hypersensitivity. *p < 0.05, compared with vehicle (Veh). (C) αAR antagonist phentolamine (Phen) did not produce any effect in NCI-treated rats. (D) Administration of Prop at 2 mg/kg did not produce any effect on AWR scores in age-matched healthy control rats.