Fig. 1.

Activated cell populations of CD4+ T-cells Δq4 (a) and/or of activated CD8+ T-cells Δq8 (b) between the MBP-treated and the respective untreated samples. Significantly more activated T-lymphocytes were observed in samples from MS patients following an overnight incubation with MBP compared to samples from healthy controls (HCs). The effect was stronger for human total MBP than for human MBP 104–118 fragment an than fot guinea pig MBP 68–82 fragment. HC-ConA/HC-Alb/HC-huMBP/HC-huMBP114/HC-gpMBP68–82: Blood from HC incubated with concanavalin A, human albumin, human total MBP, huMBP104–118 peptide and/or guinea pig MBP 68–82 peptide. MS-ConA/MS-Alb/MS-huMBP/MS-huMBP114/MS-gpMBP68–82: blood from MS patients incubated with concanavalin A, human albumin, human MBP, human MBP104–118 peptide and/or guinea pig MBP 68–82 peptide (*significantly different, p < 0.01)