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. 2015 Nov 2;12:181. doi: 10.1186/s12985-015-0412-3

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© Shimojima et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Anti-SFTS virus effects and cytotoxicity of combinations of ribavirin/IFNs. The anti-viral effects a and cytotoxicity b of ribavirin/IFNs were measured as described in Fig 1. Concentrations of the drugs used were ribavirin 43 μg/ml, IFNα 29 U/ml, IFNβ 24 U/ml, and IFNγ 12 ng/ml, EC₉₀ of each drug in the inhibition of SFTS virus infection. Experiments were performed in triplicate and means ± standard deviation are shown (n = 3). *,P < 0.05; **,P < 0.01 (unpaired t-test in comparison with data from no drug)