Table 2.

Ig V_H, D, J_H, and C_H Genes of Leukemic B Cells in Five IgA and/or IgG CLLs

		VH Gene
				CDR1 and CDR			FR1, FR2, and FR3
Patient	CH Gene	Closest Germline Gene	Nucleotide Identity %	R	p	S	R	p	S	D Gene	JH Gene	Intraclonal Divergence
TR	α	VH251 (V5-51)	100.0	0 (0.00)	—	0	0 (0.00)	—	0	LR3	JH4	No
KA	α	DP-14 (V1-18)	97.9	4 (1.17)	1.65 × 10−2 *	1	1 (4.07)	2.17 × 10−2 *	0	ND	JH4	No
GR	α	DP-42 (V3-53)	97.6	0 (0.00)	—	0	2 (5.29)	2.50 × 10−2 *	5	XP4	JH4	No
TE	α/γ	VH26 (V3-23)	88.8	13 (7.70)	1.93 × 10−2 *	1	11 (25.33)	9.00 × 10−6 *	8	ND	JH4	No
SC	γ	VH4.21 (V4-34)	95.9	1 (3.36)	0.10	0	7 (10.89)	3.71 × 10−2	4	ND	JH6	No

Abbreviations: R, number of detected and (expected) R mutations; S, number of detected S mutations; p, probability; ND, not determined.

^*Statistically significant.