Fig. 7.

AQP4 deficiency promoted decreases in BDNF production in 12-month old APP/PS1 mice. a Representative bands of Western bolt and b densitometry analysis of BDNF levels in the hippocampus and cortex. c ELISA analysis of BDNF levels in the hippocampus and cortex. Data represent mean ± SEM from 5 to 6 mice (3–4 female, and 1–2 male) per group. The statistical analysis was performed by ANOVA with post hoc Student-Newman-Keuls test. *P < 0.05; **P < 0.01; ***P < 0.001