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. 2015 Oct 28;8(5):387–399. doi: 10.1016/j.tranon.2015.08.002

Figure 4.

Figure 4

(A) BMI1-associated changes in gene expression could affect pathways relevant to cellular adhesion. Blue thermometers indicate a downregulation of gene expression in NHUC-BMI1 (relative to NHUC); and red thermometers, overexpression. (B) A trend of increased adhesion was seen in NHUC ectopically overexpressing BMI1 from three donors compared with NHUC. (C) Overexpression of BMI1 increased Transwell migration of NHUC from three of three donors investigated. Data are representative of three or two independent experiments. Errors bars show plus and minus standard deviation of triplicates repeats within each experiment. *P < .05, unpaired t test. (D) Knockdown of BMI1 repressed adhesion in 97-7, UC cell line.