Table 4.
Analysis of NHUC-BMI1 Gene List by Protein Function
| # | Pathway Maps | Total | P Value | Min FDR | P Value | FDR | In Data | Network Objects from NHUC-BMI1 Data |
|---|---|---|---|---|---|---|---|---|
| 1 | Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganization | 40 | 9.613E-06 | 3.711E-03 | 9.613E-06 | 3.711E-03 | 8 | ROCK, MLCK, PKA-cat (cAMP-dependent), G-protein alpha-s, Calmodulin, BETA-PIX, MLCP (reg), MLCP (cat) |
| 2 | Apoptosis and survival_BAD phosphorylation | 42 | 1.408E-05 | 3.711E-03 | 1.408E-05 | 3.711E-03 | 8 | PKA-cat (cAMP-dependent), JNK1(MAPK8), PI3K cat class IA, G-protein alpha-s, p90Rsk, PP2C, IRS-1, Cytochrome c |
| 3 | Development_A2A receptor signaling | 43 | 1.689E-05 | 3.711E-03 | 1.689E-05 | 3.711E-03 | 8 | CREB1, PDZ-GEF1, PKA-cat (cAMP-dependent), JNK(MAPK8-10), PI3K cat class IA, G-protein alpha-s, p90Rsk, BETA-PIX |
| 4 | Transcription_CREB pathway | 49 | 4.563E-05 | 5.979E-03 | 4.563E-05 | 5.979E-03 | 8 | CREB1, PKA-cat (cAMP-dependent), PI3K cat class IA, G-protein alpha-s, Calmodulin, p90Rsk, IRS-1, PP1-cat |
| 5 | Signal transduction_cAMP signaling | 38 | 6.170E-05 | 5.979E-03 | 6.170E-05 | 5.979E-03 | 7 | GSK3 alpha/beta, RAP-2A, CREB1, PKA-cat (cAMP-dependent), G-protein alpha-s, PKC, Calmodulin |
| 6 | Translation_Regulation of translation initiation | 27 | 6.940E-05 | 5.979E-03 | 6.940E-05 | 5.979E-03 | 6 | eIF4A, eIF1, eIF3S8, eIF5, eIF1A, eIF5B (IF-2) |
| 7 | Signal transduction_Activation of PKC via G-Protein coupled receptor | 52 | 7.098E-05 | 5.979E-03 | 7.098E-05 | 5.979E-03 | 8 | GSK3 beta, MLCK, PKC-lambda/iota, Calmodulin, PKC-mu, NF-AT2(NFATC1), MLCP (reg), MLCP (cat) |
| 8 | Translation _Regulation of EIF2 activity | 39 | 7.348E-05 | 5.979E-03 | 7.348E-05 | 5.979E-03 | 7 | GSK3 alpha/beta, PI3K cat class IA, Casein kinase I, DYRK2, IRS-1, PKR, PP1-cat |
| 9 | Cell cycle_Influence of Ras and Rho proteins on G1/S Transition | 53 | 8.166E-05 | 5.979E-03 | 8.166E-05 | 5.979E-03 | 8 | GSK3 beta, ROCK2, MLCK, JNK1(MAPK8), PI3K cat class IA, CDK6, MLCP (reg), MLCP (cat) |
| 10 | Cytoskeleton remodeling_Cytoskeleton remodeling | 102 | 9.588E-05 | 6.318E-03 | 9.588E-05 | 6.318E-03 | 11 | eIF4A, GSK3 beta, ROCK, ROCK2, MYLK1, MLCK, PI3K cat class IA, TGF-beta receptor type I, PTEN, MLCP (reg), MLCP (cat) |