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. Author manuscript; available in PMC: 2015 Nov 3.
Published in final edited form as: Mol Microbiol. 2012 Sep 19;86(4):836–844. doi: 10.1111/mmi.12021

Figure 2. Unliganded MurA binds substrates, UDP-NAG and PEP, in an ordered fashion.

Figure 2

Upon binding both substrates, MurA undergoes catalysis. Fosfomycin is a dead-end inhibitor that requires UDP-NAG binding to inactivate MurA. PDB entries: open (1DLG), UDP-NAG bound (3KQJ), tetrahedral intermediate (1A2N), and UDP-NAG/fosfomycin (1UAE). Figures were generated using PyMOL (Schrödinger, 2010).