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. 2015 Aug 18;80(5):1042–1050. doi: 10.1111/bcp.12691

Table 2.

Parameter estimates from non-compartmental pharmacokinetic analysis of oseltamivir and oseltamivir carboxylate

	Non-pregnant		Pregnant
	OS	OC	OS	OC
C_max (ng ml^–1)	71 ± 36	397 ± 113	85 ± 43	318 ± 107^**
AUC(0,t_last) (ng ml^–1 h)	145 ± 46	3507 ± 992	178 ± 68^*	2653 ± 928^**
CL/F (l h^–1)	569 ± 173	23 ± 6	478 ± 168^*	33 ± 16^**
V_d,ss/F (l)	1909 ± 860	149 ± 35	1342 ± 635^**	184 ± 73^*
t_1/2 (h)	3.0 ± 1.9	5.9 ± 1.5	3.8 ± 1.7	6.3 ± 2.2

Values are represented as mean ± SD;

^*P < 0.05 and

^**P < 0.01 vs. non-pregnant, unpaired two sided t-test