Table 1.
Mean (SD) baseline demographics
| PF-05231023 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | 0.5 mg | 1.5 mg | 5 mg | 15 mg | 50 mg | 100 mg | 200 mg | |||
| n = 14 | n = 10 | n = 10 | n = 10 | n = 10 | n = 10 | n = 10 | n = 10 | |||
| Age (years) | 52.9 (6.8) | 59.4 (4.1) | 58.4 (3.9) | 53.8 (7.2) | 53.3 (8.2) | 54.5 (8.6) | 55.2 (7.3) | 57.2 (5.7) | ||
| Weight (kg) | 85.1 (13.0) | 81.1 (8.2) | 83.6 (10.7) | 93.6 (13.1) | 87.6 (16.3) | 95.7 (14.7) | 81.2 (12.2) | 86.1 (10.9) | ||
| Height (cm) | 167.6 (9.3) | 164.3 (9.8) | 167.6 (11.0) | 172.7 (9.1) | 170.7 (10.5) | 172.2 (9.8) | 164.7 (8.0) | 169.1 (10.6) | ||
| BMI (kg m–2) | 30.3 (3.4) | 30.1 (2.8) | 29.7 (1.9) | 31.4 (3.5) | 29.9 (3.6) | 32.1 (2.1) | 29.8 (2.9) | 30.1 (2.6) | ||
| Race (% white) | 100 | 90 | 90 | 80 | 90 | 90 | 100 | 90 | ||
| Gender (% male) | 64 | 60 | 70 | 80 | 80 | 70 | 80 | 70 | ||
| HbA1c (%) | 8.6 (1.1) | 9.0 (0.9) | 8.3 (0.6) | 8.9 (0.7) | 8.9 (1.1) | 8.6 (0.7) | 8.2 (1.1) | 8.1 (0.8) | ||
| TG (mg dl–1) | 210 (75) | 148 (65) | 187(74) | 213 (130) | 208 (115) | 291 (177) | 194 (120) | 182 (72) | ||
| FPG (mg dl–1) | 166 (32) | 180 (31) | 168 (38) | 174 (46) | 172 (35) | 192 (37) | 173 (41) | 165 (36) | ||
| Con-Med (% metformin) | 93 | 100 | 100 | 80 | 100 | 80 | 90 | 100 | ||
Abbreviations are as follows: BMI, body mass index (= weight/(height/100)2); Con-Med, concomitant medication; FPG, fasting plasma glucose; HbA1c, glycosylated haemoglobin; n, number of subjects; SD, standard deviation; TG, fasting triglyceride.