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Time course of imatinib depletion and formation of desmethyl imatinib in primary cultures of human hepatocytes treated with either DMSO (○), ritonavir 10 μm (●) and ketoconazole 10 μm (□) [A, B] or DMSO (○), efavirenz 10 μm (●) and rifampicin 10 μm (□) [C, D]. Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation
