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Imatinib depletion and formation of desmethyl imatinib (CGP74588) in primary cultures of human hepatocytes treated with either DMSO or ritonavir simulating acute and chronic imatinib exposure at 2.5 μm [A] or 10 μm [B]. Decrease in imatinib between 0 and 24 h is indicated in the graphs. The open circle (○) indicates imatinib depletion and the cross (x) represents the formation of desmethyl imatinib
