Figure 6.

Induction of the general stress response by both activation and de-repression

• A–C Schematic illustration of HSP12 regulation under different environmental conditions (top). Hsp12-GFP levels of the relevant knockout strains in log phase (A), redox stress (B), and osmotic stress (C) are shown (bottom).
• D Regulatory design pattern in the activation of the general stress response. The activation of a gene depends both on the de-repression of its direct activator and on the de-activation of its direct repressor. This network design contributes to the robustness in the induction and the termination of the response.