Fig. 1.
In vivo tumor treatment experiments. C57BL/6 mice (5 per group) were injected with 2 × 105/mouse of MOSEC/luc intraperitoneally on D0. Four days later, mice were injected i.p. with a low-dose poly(I:C) (1 μg/mouse), a high-dose poly(I:C) (20 μg/mouse), a low-dose poly(I:C) in combination with PEI (0.16 μl/mouse, N/P = 8), PEI(0.16 μl/mouse), or equal amount of PBS (200 μl). The injections were repeated every 5 days until the mice died. Mice were imaged with IVIS-200 system at baseline and every week to monitor the therapeutic effects. a Bioluminescence images of the representative MOSEC/luc tumor-bearing mice at different time points after tumor inoculation. b Linear graph depicting the luminescent intensity of tumor-bearing mice treated with the different treatments. Data are represented as mean ± SD. c Kaplan–Meier survival analysis of MOSEC/luc tumor-bearing mice treated with the different treatments (*indicates P < 0.05). Data shown are representative of two experiments conducted