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. 2015 Oct 29;8:135–148. doi: 10.2147/SCCAA.S86925

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© 2015 Davy et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Analysis of the effect of iCP transplantation on remodeling of the left ventricle.

Notes: Representative images of Masson’s Trichrome staining of hearts from each group in the study demonstrating a reduction in untoward remodeling of hearts receiving cell transplants compared with control hearts (CTL) (A). Morphometric analysis of the effect of iCPs on infarct recovery showed animals receiving cell transplants had a significantly smaller circumferential infarct size than control animals (***P<0.001; **P<0.01); however, no significant difference in infarct size was observed between hearts receiving different cell transplants (B). Hearts receiving iCP transplants had significantly smaller areas at risk in the left ventricle compared with control hearts (***P<0.001) as well as to hearts receiving CD34⁺Lin^neg cells (HSC) or ASCs (*P<0.05) (C) (CTL n=5; HSC n=8; ASCs n=7; iCPs n=9).

Abbreviations: iCPs, induced cardiac-like progenitors; CTL, control; HSC, hematopoietic stem cell; ASCs, adipose-derived stem cells.