Figure 1.
Disturbed rich-club organization in schizophrenia.
Notes: (A) The rich-club members in both the healthy and psychiatric populations included the bilateral precuneus, the superior frontal cortex, the superior parietal cortex, and the insula. (B) The edges in individual brain networks (both controls and patients) were divided into three distinct classes: rich-club connections linking rich-club members (red), feeder connections linking rich-club members to non-rich-club members (orange), and local connections connecting non-rich-club members (yellow). The figure on the right shows a significant reduction in the density of rich-club connections, but not feeder or local connections, in psychiatric patients. Adapted from: van den Heuvel MP, Sporns O, Collin G, et al. Abnormal rich-club organization and functional brain dynamics in schizophrenia. JAMA Psychiatry. 2013;70(8):783–792. Copyright © 2013 American Medical Association. All rights reserved.28
Abbreviation: ROI, region of interest.