Table 1.

Summary of the available methods used to detect 5mC and oxi-mCs

Base	Affinity based Approach	Single nucleotide resolution
5mC	MeDIP	WGBS, RRBS
5hmC	CMS-IP, GLIB, 5hmC-IP, hMe-Seal, JBP1 IP	TAB-seq, oxBS-seq, oxRRBS
5fC	5fC-IP, 5fC-pulldown, 5fC-Seal	fCAB-seq
5caC	5caC IP	caCAB-seq

Abbreviations: MeDIP: methylated DNA immunoprecipitation (IP); WGBS: whole-genome bisulfite sequencing; RRBS: reduced-representation bisulfite sequencing; CMS: cytosine methylenesulfonate; GLIB: glucosylation, periodate oxidation, biotinylation; hMe-Seal: 5-hmC selective chemical labeling; TAB-seq: TET assisted bisulfite sequencing; oxBS-seq: Oxidative bisulfite sequencing; 5fC-Seal: 5-fC selective chemical labeling; CAB-seq: Chemically assisted bisulfite sequencing