Fig. 5.

Young and aged Rad^−/− hearts show increased fibrosis, without an observable effect on myocardial stiffness A: representative images from of Masson's trichome-stained sections showing increasing fibrosis in Rad^−/− from 4 and 20 mo. B: significantly more fibrosis is measured in trichrome stained hearts from Rad^−/− compared with WT in both young and aged mice. C: E:A ratio is unchanged and remains above 1 for both WT and Rad^−/− in old age. *P < 0.05, **P < 0.01 vs. WT; n = 3–6 mice.