A–D: influence of age and PNE on the breathing frequency (f) response to changing inspired oxygen levels: 50, 16, 12, and 10% O2, respectively. Each panel shows the Δf on the y-axis, and postnatal age on the x-axis. The results of statistical analyses are given in Table 1 and in the text of results. There were no significant between-group effects, nor age-treatment group interactions.