Skip to main content
. 2015 Nov 3;10(11):e0141550. doi: 10.1371/journal.pone.0141550

Fig 8. Differential regulation of IL-23 and IL-12 productions in T. gondii-infected THP-1 cells upon pretreatment with specific inhibitor of p38 MAPK, ERK1/2 or JNK.

Fig 8

The p38 inhibitor (SB203580), ERK inhibitor (PD98059), or JNK inhibitor (SP600125) was added to THP-1 cells at the concentrations indicated at 1 h before infection with T. gondii. The culture supernatants were harvested after 18 h for cytokine assessment using ELISA. The IL-23 and IL-12 levels following stimulation with T. gondii with or without the presence of p38 MAPK inhibitor (A), ERK1/2 inhibitor (B), or JNK inhibitor (C) are shown. The solvent control was 0.1% DMSO. One representative experiment performed in triplicate is shown.* P<0.05 compared with DMSO-treated T. gondii-infected group.