Table 1. Dual islet transplant recipients.

A. There were 10 recipients of WT and GTKO NPIs, 5 for each endpoint. IEq/kg was matched as closely as possible for transplant. Glucose simulation index (GSI) was over 1.0 for all islets confirming glucose sensitive insulin production.

B. There were 6 recipients of GTKO NPIs and MS, 3 for each endpoint. IEq/kg of MS was determined by counting of spheres using the same technique as islets and matching for infused islet volume.

a) WT vs GTKO NPI recipients
Recipient ID	Weight	Endpoint	Left lobe	IEq/kg	GSI	Right Lobe	IEq/kg	GSI
WTGTKO1	4.5 kg	1 hour	WT NPI	50,822	1.69	GTKO	52,792	2.43
WTGTKO2	4.94 kg	1 hour	GTKO	26,895	2.29	WT NPI	25,641	2.82
WTGTKO3	9.3 kg	1 hour	WT NPI	25,228	5.7	GTKO	24,912	3.77
WTGTKO4	3.57 kg	1 hour	GTKO	52,822	1.46	WT NPI	58,272	1.69
WTGTKO5	8.35 kg	1 hour	WT NPI	26740	2.68	GTKO	26,734	3.52
WTGTKO6	7.55 kg	24 hour	GTKO	25,320	2.92	WT NPI	25,296	2.82
WTGTKO7	6.14 kg	24 hour	WT NPI	24,868	2.82	GTKO	25,317	2.29
WTGTKO8	7.15 kg	24 hour	GTKO	26,381	3.07	WT NPI	24,604	2.29
WTGTKO9	9.5 kg	24 hour	GTKO	25,976	4.11	WT NPI	25,976	3.11
WTGTKO10	3.2 kg	24 hour	GTKO	31,172	8.26	WT NPI	32,203	7.97
b) GTKO NPI vs MS recpients
Recipient ID	Weight	Endpoint	Left lobe	IEq/kg	GSI	Right Lobe	IEq/kg	GSI
MSGTKO1	8.7 kg	1 hour	GTKO	26,000	2.3	Sphere	matched	N/A
MSGTKO2	7.0 kg	1 hour	GTKO	26,244	7.23	Sphere	matched	N/A
MSGTKO3	10.0 kg	1 hour	GTKO	19,835	4.92	Sphere	matched	N/A
MSGTKO4	4.05 kg	24 hour	Sphere	matched	N/A	GTKO	20,903	1.67
MSGTKO5	8.8 kg	24 hour	Sphere	matched	N/A	GTKO	25,568	2.96
MSGTKO6	9.97 kg	24 hour	GTKO	25,075	5.17	Sphere	matched	N/A