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. Author manuscript; available in PMC: 2016 Nov 30.
Published in final edited form as: Psychiatry Res. 2015 Sep 14;234(2):164–171. doi: 10.1016/j.pscychresns.2015.08.015

Table 1.

Regions of interest sizes, coordinates and literature-based selection criteria.

ROI Chosen for MNI
coordinates
vmPFC Anterior hub of DMN 0, 54, −8
dlPFC Cognitive control network −28, 22, 52 30, 22, 52
PCC Posterior hub of DMN 0, −56, 28
pgACC Altered functional connectivity in depression −8, 41, 5 8, 41, 5
sgACC Altered metabolism and functional connectivity in depression; Target for DBS treatments for depression 0, 21, −10
Anterior Thalamus Rich serotonergic innervation with frontal projections −10, −12, 12 10, −12, 12
Dorsal Raphé Origin of serotonergic neurons; Involvement in action of SRI antidepressant treatments Subject-specific

pgACC, sgACC, and anterior thalamus ROIs were conservatively created as 5 mm radius spheres. As standard in CONN toolbox, dlPFC, vmPFC, and PCC volumes approximated 10 mm radius spheres. For the dorsal raphé, each subject-specific rectangular volume was hand-drawn as detailed in the text. Raphé sizes ranged from 3 to 10 voxels of 8 mm3.

DBS = deep brain stimulation; dlPFC = dorsolateral prefrontal cortex; DMN = default mode network; PCC = posterior cingulate cortex; pgACC = pregenual anterior cingulate cortex; ROI = region of interest; sgACC = subgenual anterior cingulate cortex; SRI = serotonin reuptake inhibitor; vmPFC = ventromedial prefrontal cortex.