Table 2.

Changes in dorsal raphé resting-state functional connectivity with acute tryptophan depletion in SSRI-treated major depressive disorder.

Frequency band (Hz)	Participant group	Thalamus left		Thalamus right		pgACC left		pgACC right
		ΔZ(r)	p	ΔZ(r)	p	ΔZ(r)	p	ΔZ(r)	p
0.01–0.1	All participants, n = 15	0.05	0.21	0.01	0.86	0.03	0.63	0.09	0.13
	Remitters, n = 10	0.08	0.16	0.00	0.95	−0.05	0.50	0.03	0.63
	Non-remitters, n = 5	−0.01	0.81	0.02	0.85	0.18	0.19	0.20	0.12
	Remitters vs. Non-rem.	0.10	0.28	−0.02	0.88	−0.22	0.09	−0.17	0.18
0.01–0.025	All participants	−0.17	0.15	−0.20	0.20	0.14	0.20	0.06	0.65
	Remitters	−0.14	0.28	−0.25	0.17	0.01	0.96	−0.01	0.96
	Non-remitters	−0.23	0.36	−0.10	0.76	0.41	0.10	0.21	0.29
	Remitters vs. Non-rem.	0.09	0.71	−0.15	0.64	−0.41	0.09	−0.22	0.47
0.025–0.05	All participants	0.19	0.01	0.18	0.05	−0.09	0.21	0.09	0.32
	Remitters	0.15	0.09	0.08	0.44	−0.18	0.02	0.08	0.46
	Non-remitters	0.26	0.04	0.38	0.07	0.09	0.58	0.10	0.51
	Remitters vs. Non-rem.	−0.11	0.39	−0.30	0.11	−0.27	0.08	−0.02	0.92
0.05–0.1	All participants	0.08	0.29	0.00	0.97	0.02	0.74	0.12	0.03
	Remitters	0.14	0.16	0.07	0.38	0.02	0.83	0.07	0.19
	Non-remitters	−0.06	0.52	−0.16	0.37	0.03	0.76	0.22	0.14
	Remitters vs. Non-rem.	0.20	0.19	0.23	0.16	−0.01	0.94	−0.15	0.18

Changes in functional connectivity (ΔZ(r)) between sham and ATD (Z(r) sham minus Z(r) ATD) for dorsal raphé to the selected ROIs. We also examined changes in functional connectivity of dorsal raphé with the bilateral dlPFC, and midline sgACC, vmPFC and PCC ROIs. These data are not presented in Table 2 because none of these regions demonstrated significantly altered functional connectivity with the dorsal raphé during ATD.

ATD = acute tryptophan depletion; dlPFC = dorsolateral prefrontal cortex; PCC = posterior cingulate cortex; pgACC = pregenual anterior cingulate cortex; sgACC = subgenual anterior cingulate cortex; SSRI = selective serotonin reuptake inhibitor; vmPFC = ventromedial prefrontal cortex.