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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Neurosci Lett. 2015 Sep 10;607:46–51. doi: 10.1016/j.neulet.2015.09.005

Figure 1.

Figure 1

Flupirtine pretreatment effectively blocks hypoxia-induced behavioral seizures. All the P10 rat pups pretreated with 50 (5/5), 45 (3/3) or 35 (5/5) mg/kg flupirtine that were exposed to graded global hypoxia remained seizure free, i.e., none of them developed behavioral seizures during hypoxia. None of the rats pretreated with vehicle (12/12) and 60% rats pretreated with 25mg/kg flupirtine (5/8) remained seizure free. Statistical comparisons were made individually between the vehicle treated group and each of the flupirtine treated groups. *p<0.005, Fisher's exact test. Hy = Hypoxia, Veh = Vehicle, Flup = Flupirtine.