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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Brain Behav Immun. 2015 Jul 15;50:196–202. doi: 10.1016/j.bbi.2015.07.014

Figure 1.

Figure 1

Blockade of NF-κB reduces CFA-induced mechanical and thermal pain in rats. Intraplantar administration of CFA (200 μL) increases (A) mechanical allodynia, (B) mechanical hyperalgesia, and (C) thermal hyperalgesia. Pretreatment with MG132 (20 mg/kg dosage) attenuates mechanical allodynia and thermal hyperalgesia compared to Vehicle + Saline group. N=8 per group. Data are mean ± SEM. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 different from Vehicle + Saline for larger graphs and different from Vehicle for inset graphs.