. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Diabetologia. 2015 Sep 13;58(12):2736–2744. doi: 10.1007/s00125-015-3740-3

Table 3.

HRs (95% CIs) for incident prediabetes and diabetes by self-reported marijuana use; CARDIA examination Y7–25 (1992–1993 to 2010–2011)

	Lifetime frequency of marijuana use
	Never use	1–9 times	10–99 times	≥100 times	p for trend^a
Prediabetes
No. cases/n	275/548	329/660	333/692	473/858
Incidence, per 100,000 person-years	3,628	3,607	3,415	4,084
Crude HR (95% CI)	1.00 (ref.)	0.99 (0.84, 1.16)	0.93 (0.79, 1.09)	1.15 (0.99, 1.33)	0.07
Adjusted HR (95% CI)^b	1.00 (ref.)	1.13 (0.96, 1.34)	1.21 (1.00, 1.45)	1.39 (1.13, 1.71)	<0.01
Adjusted HR (95% CI)^c	1.00 (ref.)	1.13 (0.95, 1.33)	1.21 (1.00, 1.45)	1.40 (1.13, 1.72)	<0.01
Diabetes
No. cases/n	81/625	79/738	85/774	106/1,014
Incidence per 100,000 person-years	811	667	685	649
Crude HR (95% CI)	1.00 (ref.)	0.82 (0.60, 1.11)	0.84 (0.62, 1,14)	0.78 (0.59, 1.05)	0.15
Adjusted HR (95% CI)^b	1.00 (ref.)	0.94 (0.68, 1.29)	1.28 (0.90, 1.83)	1.10 (0.74, 1.64)	0.45
Adjusted HR (95% CI)^c	1.00 (ref.)	0.93 (0.68, 1.29)	1.30 (0.91, 1.86)	1.16 (0.77, 1.74)	0.32

A test for linear trend across marijuana use category

Adjusted for Y7 covariate values for age, sex, race, smoking, alcohol, education, field centre, diet quality, physical activity, SBP, LDL-cholesterol, HDL-cholesterol, medication use and use of other illicit drugs

As for the model described above, with the addition of BMI, BMI² and WC