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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Brain Behav Immun. 2015 Jul 17;50:288–297. doi: 10.1016/j.bbi.2015.07.017

Figure 1. Reversal of TLR2 upregulation following naltrexone treatment.

Figure 1

We hypothesized that naltrexone treatment would result in a reduction of inflammatory events that we observed in macaques with self-injurious behavior (Lee et al., 2013b). Astrocytes of control animals were generally immunonegative for TLR2 (A, and graph). There was an increase in GFAP/TLR2 double-positive white matter astrocytes in SIB animals (B). This proportion of double-positive astrocytes was significantly reduced following treatment with naltrexone, although it was still significantly higher then in control animals (C). Data is shown as shown as mean ± SD, * indicates significance from Control animals (p < 0.05), # indicates significance from SIB animals (p < 0.05).