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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Nutr Biochem. 2015 Jun 20;26(11):1208–1220. doi: 10.1016/j.jnutbio.2015.05.012

FIGURE 6. The proposed action of developmental DEHP exposure on adipose tissue in male offspring in the current model.

FIGURE 6

Our data suggest that in utero DEHP exposure in males was associated with decreased fat mass, potentially due to a decrease in adipocyte number at birth (A). DEHP-exposed male offspring experienced catch-up adipogenesis at weaning, potentially due to an increase in lipid accumulation and de novo fatty acid synthesis (B). Adult males developmentally exposed to DEHP had increased adiposity and cell perimeter, but fewer small/medium-sized adipocytes and decreased overall cell number. Furthermore, these adult males had glucose intolerance when they also consumed a high-fat diet after weaning.