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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Mutat Res. 2015 Aug 30;781:14–21. doi: 10.1016/j.mrfmmm.2015.08.007

Fig. 1. Both normal and FRDA cells show a high frequency of spontaneous chromosomal abnormalities in the region of the FXN gene.

Fig. 1

A) The percentage of abnormal chromosomes seen in normal and patient lymphoblastoid cells. B) Examples of the chromosomal abnormalities observed in these cells. (i) Chromosome with a duplication on one sister chromatid. (ii) Chromosome with a deletion on one sister chromatid. (iii) Chromosome with a duplication on one chromatid and a deletion on the other. Chromosomes were stained with DAPI (blue) and FXN signal is shown in red. Chromosomal duplications made up 76–90% of the chromosomal abnormalities with the remainder being deletions of some or all of the probe region.