TABLE 1 .
Parameter values for the full model for estimation of linezolid impact on total MTB burden and the less linezolid-susceptible subpopulationa
| Parameter (units) | Mean | Median | SD |
|---|---|---|---|
| Vol (liters) | 65.2 | 65.2 | 1.21 |
| CL (liters/h) | 12.2 | 13.2 | 1.79 |
| Kg,max-s (h−1) | 0.754 | 0.699 | 0.206 |
| Kg,max-r (h−1) | 0.0208 | 0.0210 | 0.00518 |
| Kk,max-s (h−1) | 3.25 | 3.66 | 0.624 |
| Kk,max-r (h−1) | 1.21 | 0.752 | 0.885 |
| C50,k-s (mg/liter) | 3.68 | 3.74 | 0.496 |
| C50,k-r (mg/liter) | 18.7 | 17.0 | 2.873 |
| Hk-s | 10.9 | 14.3 | 4.39 |
| Hk-r | 13.8 | 14.6 | 10.1 |
| POPMAX (CFU/ml) | 3.72 × 107 | 4.84 × 107 | 1.50 × 107 |
| Initcond_2 (CFU/ml) | 1.81 × 107 | 1.43 × 107 | 9.66 × 106 |
| Initcond_3 (CFU/ml) | 5.90 | 0.601 | 8.35 |
Vol is the apparent volume of the central compartment; CL is the apparent plasma clearance; Kg,max-s and Kg,max-r are maximal growth rate constants for the susceptible and resistant populations; Kk,max-s and Kk,max-r are maximal kill rate constants for the respective populations; C50,k-s and C50,k-r are linezolid concentrations at which the kill rate is half maximal for the respective populations; Hk-s and Hk-r are Hill’s constants for the respective populations; POPMAX is the population burden at which stationary phase is achieved; Initcond_2 is the initial total MTB population burden; Initcond_3 is the initial linezolid-resistant MTB burden. It was assumed that the initial linezolid concentration was 0.0.