Table 2. Metabolites that correlate with the accumulation of fat depots and lean tissue according to the linear regression models.
| MRI assessment |
Positive correlations |
Negative correlation |
||||
|---|---|---|---|---|---|---|
| Metabolite | r2 | P | Metabolite | r2 | P | |
| Lean tissue | Lactate | 0.1 | 0.07 | Leucine | 0.16 | 0.02 |
| Valine | 0.16 | 0.02 | ||||
| Visceral adipose tissue | Leucine | 0.16 | 0.02 | Alanine | 0.12 | 0.04 |
| Valine | 0.16 | 0.02 | Lactatea | 0.06 | 0.14 | |
| Liver fat | 3-methyl-2-oxovalerate | 0.09 | 0.09 | Alanine | 0.08 | 0.09 |
| Total body fat | 3-hydroxybutyratea | 0.04 | 0.25 | Alanine | 0.18 | 0.01 |
| 3-methyl-2-oxovalerate | 0.16 | 0.02 | Lactatea | 0.06 | 0.15 | |
| Acetate | 0.11 | 0.06 | ||||
| Leucine | 0.14 | 0.03 | ||||
Abbreviations: MRI, magnetic resonance imaging. Inclusion criteria for correlating metabolites; higher P(corr) than 0.5 and a higher variable importance plot (VIP) value than 2 in the OPLS models, together with a P-value lower than 0.1.
a
Included owing to the high importance when group discrimination was considered.