. 2015 Nov 4;6:261. doi: 10.3389/fphar.2015.00261

Table 2.

Influence of non-genetic factors on CYP2C8 phenotype.

Non-genetic factor^a	Association test^b	mRNA^c	Protein^c	Activity^c
SEX	WMW	0.119	0.068	0.618
AGE	Spearman	0.321	0.577	0.106
NIC	WMW	0.375	0.988	0.895
ALC	WMW	0.257	0.681	0.149
DIAG	KW	0.363	0.198	0.231
CHOL	WMW	0.053	0.013	0.087
IND	WMW	0.488	0.729	0.552
BILI	WMW	0.094	0.0004	0.003
GGT	WMW	0.51	0.041	0.019
CRP	WMW	0.622	0.083	0.403

^aNIC, nicotine consumption: non-smokers vs. smokers (>1 cigarettes/day); ALC, alcohol consumption: none vs. >1 times/week; IND, exposure to known inducers of P450; BILI, serum total bilirubin; GGT, serum gamma glutamyl transferase; CRP, C-reactive protein; DIAG, diagnosis; CHOL, cholestasis.

^bWMW, Wilcoxon–Mann–Whitney test; Spearman, Spearman’s correlation test; KW, Kruskal–Wallis test.

^cp-values for univariate analyses using the given association test and were not corrected for multiple testing; p-values significant after Bonferroni correction are shown in bold type.