Table 2. Association of rs4803217 with the pre-treatment viral load.
coefficient | P | (after correcting for rs12979860) | coefficient | P | P (after correcting for rs12979860) | |
---|---|---|---|---|---|---|
Discovery SNP in GWAS | ||||||
rs12979860-C | 12.89 | 7.81 × 10−7 | - | 20.68 | 5.41 × 10−6 | - |
Candidate functional variant | ||||||
rs4803217-G | 12.61 | 1.35 × 10−6 | 0.793 | 21.25 | 2.25 × 10−6 | 0.196 |
rs368234815-TT | 13.03 | 5.77 × 10−7 | 0.412 | 22.20 | 7.57 × 10−7 | 0.037 |
European-American N = 792 | African-American N = 169 | |||||
Comparison between functional SNPs | coefficient | P | coefficient | P | ||
rs4803217-G (correcting for rs368234815-TT) | -5.79 | 0.677 | 9.04 | 0.253 | ||
rs368234815-TT (correcting for rs4803217-G) | 18.71 | 0.178 | 14.61 | 0.066 |
Association tests were performed by linear regression or multiple linear regression (additive genetic model).