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. 2015 Nov 4;5:16067. doi: 10.1038/srep16067

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Copyright © 2015, Macmillan Publishers Limited

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(A) The invasion and migration of the SU.86.86 cells were decreased after GRP78 knockdown compared to the NC group (*p < 0.01). (B) The invasion and migration of the BXPC-3 cells were decreased after GRP78 knockdown compared to the NC group. (C) The invasion and migration of the Capan-1 cells were increased after the forced overexpression of GRP78 compared to the NC group (*p < 0.01, original magnification, 100×). (D) The levels of RhoA, ROCK1, JAK2, vimentin, Smad4, and p-STAT3 were decreased by GRP78 knockdown and increased by GRP78 overexpression in the SU86.86, BXPC-3 and Capan-1 cell lines (*p < 0.05). siRNA, siRNA-GRP78; OE-GRP78, overexpression of GRP78; NC, negative control. Cropped blots/gels were used in the figure and the gels had been run under the same experimental conditions; the full-length blots/gels are presented in Supplementary Figure S5.