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. 2015 Nov 4;6:1230. doi: 10.3389/fmicb.2015.01230

FIGURE 1.

FIGURE 1

Heroin enhances HIV infection of macrophages. (A) Seven-day cultured macrophages were incubated with or without heroin at indicated concentrations for 6 h prior to different HIV strain (Bal, JRFL, or JAGO) infection. HIV RT activity was determined at day 12 postinfection. (B) Seven day cultured macrophages were incubated with or without heroin at the indicated concentrations for 6 h prior to HIV (Bal) infection. HIV RT activity was determined at day 6, 10, and 12 postinfection. Cell culture supernatant was collected at the indicated time points and subjected to RT assay to detect HIV RT activity. The data shown is the mean ± SD of triplicate cultures representative of three experiments using cells from three different donors (∗p < 0.05, ∗∗p < 0.01, heroin vs. control).