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Heroin inhibits IFN-α and IFN-β. Naltrexone (10-6 M) was added to the macrophage cultures for 1 h prior to heroin treatment. Total cellular RNA was then extracted from the cell cultures 6 h post-treatment and subjected to realtime RT-PCR for IFN-α (A) and IFN-β (B) expression. The data shown is the mean ± SD of triplicate cultures representative of three experiments using cells from three different donors (∗p < 0.05, ∗∗p < 0.01, heroin vs. control, or heroin + naltrexone).
