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. 2015 Nov 4;5:16094. doi: 10.1038/srep16094

Figure 4. Translocation of S. typhimurium to the spleen was reduced in MET-1 pretreated mice.

Figure 4

Spleens were harvested 48 hours after S. typhimurium infection, weighed, and homogenized in 1 mL PBS. Serial dilutions were plated on MacConkey agar plates containing 100 μg/mL streptomycin. Plates were incubated at 37 °C for 24 hrs, and the resulting colonies were counted. Infected mice pretreated with MET-1 (MET-1 + S. Tm., n = 13) had reduced S. typhimurium counts in the spleen (*p < 0.05) compared to mice pretreated with vehicle control (VC + S. Tm., n = 12). S. typhimurium was not detected in the tissues of uninfected mice pretreated with vehicle control (VC, n = 12) or MET-1 (n = 12). Data were analyzed using a 1-way ANOVA with Bonferroni correction.