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. 2015 Nov 4;5:16102. doi: 10.1038/srep16102

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(a) Schematic of symptom progression in Sca1^154Q/2Q mice. (b) Compiled turnover rates of spines (ratio of spines formed and eliminated to twice the total number of spines) in 4-, 6-, and 8-week-old Sca1^2Q/2Q and Sca1^154Q/2Q mice. Sca1^154Q/2Q mice demonstrated higher spine turnover rates throughout synaptic development than Sca1^2Q/2Q mice. (c) Compiled turnover rates of filopodia at different ages (in weeks). Sca1^154Q/2Q mice showed higher filopodium turnover rates than Sca1^2Q/2Q mice from 6 weeks of age. Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, Student t-test (b) or two-way ANOVA followed by Bonferroni test (c).