Table 1.

Mouse Models Lacking Various Immune Components and its Effect on NAFLD/NASH. Upward Facing Arrow (↑) Indicates Enhanced Condition as Compared with the Respective Wild-type Control and Downward Facing Arrow (↓) Indicates Vice Versa.

Mouse strain	Deficiency	Diet inducing NAFLD	Effects	Reference
B6.129S2-Tap1tm1Arp/J	CD8+ T cell	High-fructose diet	Hepatic steatosis ↓ Insulin sensitivity ↑ Glucose intolerance ↓ Inflammation ↓	Arindkar et al.11 and Bhattacharjee et al.12
CBA/CaHN-Btkxid/J	B cell deficient	High-fructose diet	Not involved in NAFLD	Bhattacharjee et al.12
C.129S2-Cd1tm1Gru/J	CD1 deficient	High-fat diet	Hepatic steatosis ↑ Inflammation ↑	Martin-Murphy BV et al.26
B6.129S2-H2dlAb1-Ea/J	MHC II deficient	High-fat diet	Not involved in NAFLD	Gilles et al.29
B6.129P2-Cd40tm1Kik/J	CD40 deficient	High-fat diet	Hepatic inflammatory cytokines ↓ Liver steatosis ↑ Insulin resistance ↑ Glucose intolerance ↑	Guo et al.32
IRF 7−/− mice	IRF7 deficient	High-fat diet	Hepatic inflammatory cytokines ↓ Liver steatosis ↓ Insulin sensitivity ↑ Glucose tolerance↑	Wang et al.34
IRF 9−/− mice	IRF9 deficient	High-fat diet	Liver steatosis ↑ Insulin sensitivity ↓ Hepatic inflammation ↑	Wang et al.35
TLR 2−/− mice	TLR2 deficient	MCD diet	Fibrosis ↑ Steatohepatitis ↑	Chantal et al.37
TLR 9−/− mice	TLR9 deficient	CDAA diet	Steatohepatitis ↓ Fibrosis ↓	Brenner et al.41
B6.129P2(SJL) Myd88tm1.1Defr/J	MyD88 deficient	CDAA diet	Steatohepatitis ↓ Inflammation ↓ Insulin resistance ↓	Miura et al.42
B6.129S2-Il6tm1Kopf/J	IL-6 deficient	Ethanol induced	Hepatic steatosis ↑	El-Assal et al.48
Il17ratm1Koll	IL-17 deficient	High-fat diet	Hepatic steatosis ↓ Inflammation ↓	Tang et al. 52 and Xu et al.55
B6.129P2-Il10tm1Cgn/J	IL-10 deficient	High-fat diet Ethanol induced	Hepatic steatosis ↓ Inflammation ↓	Miller A et al.56
IL-1Ra−/−	IL-1 deficient	High-fat diet	Hepatic steatosis ↓ Loss in weight ↑	Negrin et al.57
B6.129S1-Mapk8tm1Flv/J	JNK1 deficient	CDAA diet	Steatohepatitis ↓ Fibrosis ↓	Yuzo et al.58
C.129S4(B6)-Miftm1Dvd/J	MIF deficient	High-fat diet MCD diet	Hepatic steatosis ↑ Inflammation ↑ Fibrosis ↓	Heinrichs et al.61, 62
129-Smad3tm1Par/J	Smad3 deficient	High-fat diet	Obesity ↓ Steatosis ↓ Glucose tolerance ↑ Insulin sensitivity ↑	Yadav et al.63
Cmklr1−/−	Cmklr1 deficient	High-fat diet	Not involved in NAFLD	Gruben et al.65
Nlrp3−/−	Nlrp3 deficient	High-fat diet	Prevent inflammation in liver	Vandanmagsar et al.64