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. 2015 Aug 14;4(11):811–822. doi: 10.1016/j.molmet.2015.08.001

Figure 5.

Figure 5

Fatty-acid potentiated insulin secretion is dependent on β-cells PGC-1s expression. (A) Insulin secretion from primary islets (n = 16–20). (B) KCl response (n = 8) and (C) insulin content of primary islets (n = 10). Data are means ± SEM. Statistical comparisons are: *p < 0.05, **p < 0.01, ****p < 0.0001 comparing treatment effect to basal (2.8 mM glucose) of similar genotype; ###p < 0.001 comparing effect of palmitate on glucose response (versus 16 mM glucose) of similar genotype; &&p < 0.01 represents genotype effect (WT fl/fl versus βPgc-1 KO). (D) OCR in primary islets (n = 5). (E) Glucose/palmitate-stimulated ATP increases in dispersed islet cells (n = 5, pooled). Data are means ± SEM, *p < 0.05 compared to islets of WT fl/fl controls.