Figure 5.

Sirt6BAC mice exhibit enhanced insulin sensitivity. (A) Glucose infusion rate (GIR) (mg glucose/kg bodyweight/minute) (B) Blood glucose (mg/dL) (C) Endogenous glucose appearance (EndoR_a) (mg/kg bodyweight/minute) (D) Glucose disposal (R_d) (mg/kg bodyweight/minute) (E) Tissue glucose uptake (R_g) (μmol/100 g tissue/minute) (F) Glycolytic rate (% of R_d). n = 6–8 per group. All mice were fed on a standard diet. Values are mean ± S.E.M. Panels A&B: Statistics were analyzed using repeated measures one-way ANOVA with Tukey correction for multiple comparisons (*p < 0.05, **p < 0.01). Panels C, D, E&F: Statistics were analyzed using unpaired two-tailed t-test (*p < 0.05, **p < 0.01).