Table IV.

Experimentally determined K_i value {K_i (Exp)} and enantioselectivity determined using the CMAC(hOCT1) column, where the stereoselectivity factor (α) is defined as the ratio of the K_i of the compound with the experimentally determined lowest affinity for the hOCT1 divided by the K_i of the compound with the highest experimentally determined affinity.

Compound	Ki (Exp) (µM)	α
(R)-verapamil	0.05
(S)-verapamil	3.46	69.2
(S)-atenolol	0.46
(R)-atenolol	0.98	2.13
(S)-propranolol	2.85
(R)-propranolol	0.95	3.04
(1R,2R)-pseudoephedrine	1.12
(1S,2S)-pseudoephedrine	1.71	1.53
Quinidine	6.33
Quinine	10.18	1.61
(S,S)-fenoterol	3.73
(R,R)-fenoterol	12.6	3.38
(S,R)-fenoterol	6.18
(R,S)-fenoterol	13.2	2.14
(S)-isoproterenol	180
(R)-isoproterenol	120	1.5
(R)-disopyramide	15.0
(S)-disopyramide	30.0	2

Note: For experimental details, see Moaddel et al. (2007b).