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. 2015 Oct 1;6(10):e1893. doi: 10.1038/cddis.2015.234

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Extrinsic cell death pathway is functional downstream from Caspase-8 and defective upstream from Caspase-8 in the majority of AZD5582/TRAIL-resistant cell lines. (a) Heat maps showing examples of two cell lines where no synergy was observed between AZD5582 and TRAIL, but significant synergy was detected between AZD5582 and TNFα. (b) Summary of synergy scores obtained with AZD5582/TRAIL and AZD5582/TNFα combination treatments, blue shading indicates moderate difference and red highlights dramatic discrepancies between synergy scores obtained with the different treatment modalities. (c) Caspase-8 activity assay in cells treated for 16 h with 30 ng/ml TRAIL in five AZD5582/TRAIL resistant and six sensitive cell lines; error bars represent S.E.M. of means of three independent experiments