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. 2015 Oct 1;6(10):e1894. doi: 10.1038/cddis.2015.241

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Metastasis in DEN-induced tumors. (a) Representative HE sections showing vascular invasion (upper panel, scale bar: 50 μm) and lung metastases (lower panel, scale bar: 500 μm). Arrows designate metastatic foci. (b) IMP2 expression in human HCCs grouped into tumors positive or negative regarding vascular invasion (91 samples; GSE20238). (c) Representative HE and Gp73 and GS immunohistochemistry (IHC) of primary liver tumor and lung metastasis in wt (n=21) and p62 tg (n=18) mice in the metastatic phase. Scale bars: liver: 200 μm; lung: 100 μm