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. 2015 Oct 1;6(10):e1894. doi: 10.1038/cddis.2015.241

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Increased levels of ROS and ROS-inducer RAC1 in p62 transgenic mice. (a) Hepatic TBARS levels in wt (n=5) and p62 tg (n=5) livers of untreated (co) and 48-h DEN-treated (DEN) animals (wt: n=8; tg: n=9). Error bars show the interquartile range. (b–d) Dlk1 (b) and Rac1 (c) mRNA expression as well as correlation of both d was investigated after 8 months (wt: n=18; tg:n=18). Error bars show the interquartile range. (e) Secreted DLK1 protein serum levels were measured by ELISA. Error bars show the interquartile range