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. 2015 Oct 15;6(10):e1920. doi: 10.1038/cddis.2015.258

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Results of radiation and chemotherapy sensitivity. (a) The growth curves of CNE2 cells transfected with NC- or FBP1-targeting (KD) siRNAs at 48 h post treatment with the indicated doses of DDP (left panel) and 5-FU (right panel). (CNE2-NC versus CNE2-siFBP1-1#1 and siFBP1-2#, P<0.001 by the paired t-test). (b) The growth curves of 5-8F cells transfected with NC- or FBP1-targeting (KD) siRNAs at 48 h post treatment with the indicated doses of DDP (left panel) and 5-FU (right panel). (5-8F-NC versus 5-8F-siFBP1-1# and 5-8F-siFBP1-2#, P<0.05, by the paired t-test). (c) The survival fraction (SF) curves (upper panel) and the representative pictures of CNE2 and 5-8F cells transfected with NC- or FBP1-targeting (KD) siRNAs at 10 days after X-ray irradiation with the indicated Gy doses (lower panel). (NC versus siFBP1-1#1 in CNE2 and 5-8F, P<0.05; NC versus siFBP1-2# in CNE2 and 5-8F, P<0.01 by the paired t-test)