Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 15;6(10):e1921. doi: 10.1038/cddis.2015.261

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Inhibition of Notch1 signaling causes an increased Caspase-8 cleavage and DISC formation upon TRAIL treatment. (a) U251MG cells transduced with control-AdV or Notch1sh-AdV (72 h) were treated with TRAIL (40 ng/ml) for the indicated times. Total cell lysates were subjected to immunoblot analysis for Notch1 and Caspase-8. Asterisk indicate cleaved Caspase-8 fragments (*=p41/p43; **=p24/p26). (b) Control-AdV and Notch1sh-AdV transduced U251MG cells (72 h) were treated with Flag-TRAIL (500 ng/ml) for the indicated time points. Subsequently, Flag was immunoprecipitated and immunoblots were probed with DR5 and Caspase-8 antibodies. Whole cell lysates were used for input controls