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. 2015 Oct 29;6(10):e1947. doi: 10.1038/cddis.2015.268

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Ataxia Telangiactesia related-protein (ATR) regulates nSMase2 transcriptionally upstream of Chk1. (a and b) MCF7 cells were seeded in 60 mm dishes, and small interfering RNA (siRNA) knockdown was performed using AS, for 24 h. After that, vehicle or doxorubicin were added and cells were collected and immunoblotted for nSMase2, ataxia telangiectasia mutated (ATM), ATR and actin (a), or RNA was isolated and transformed to cDNA and quantitative real-time PCR (qRT-PCR) was performed for nSMase2 (b), *P<0.05 and **P<0.01